DrugMatrix delivers sophisticated software for fast and easy access to the information you want—and the ability to interpret it.

The advanced query tool allows scientists to formulate and execute queries that find information in all of the integrated data domains based on any of the available information. The researcher can formulate a query combining literature-derived information on genes or compounds, pharmacological activity, expression changes, or chemical structure. Some examples include the ability to identify:

• Compounds that modulate a specific gene product
• Compounds that induce the expression of a specific gene
• Genes that are induced/repressed by a specific compound
• Genes in a specific pathway
• Compounds that affect a specific pathway
• Compounds with a specific mechanism of action or therapeutic class

Specialized query algorithms identify patterns based on structural or experimental information. DrugMatrix integrates proprietary and third-party algorithms that allow the identification of information relevant to the activities and toxicities of proprietary lead compounds. Expression array experiments and the results of pharmacology panels can be queried against the DrugMatrix database to identify compounds that elicit similar responses. Chemical structures can be queried against the assembled structures in DrugMatrix to identify structurally related reference compounds.

Create and manipulate lists of items DrugMatrix uses lists as a mechanism to allow the interactive refinement of queries. Lists, the result of individual queries, can be combined or intersected sequentially to implement highly sophisticated searches in a very user-friendly way. Lists are saved during working sessions and can be exported to use in more complex data mining sessions.

Visualize pathways The pathway visualization tool displays the relationships of gene products in a pathway and allows the overlay of expression data with selected compound treatments.

Data can be supported in multiple platforms DrugMatrix supports analysis and querying with expression data from any of two expression platform formats. Data can be read from files generated by GE Healthcare’s CodeLink®, Affymetrix’s MicroArray Suite®.

Export data to other analysis software DrugMatrix supports the analysis of pharmacological assays and expression data in commercial packages available from such companies as Spotfire. Either pharmacological assays or expression data can be exported in simple tab-delimited text files that can be used in any of these packages. The data exporter allows you to do sophisticated filtering, enabling you to only export the most relevant data.