In August of 2007, Iconix introduced DrugMatrix® Online 1.0 (DMO) - providing Web access to a full-featured version of the DrugMatrix Database and analytical tools on a single user license basis. This ground-breaking product is designed for organizations that have limited internal resources, and thus may not be able to fully leverage a Platform Alliance, but are able to carry out molecular toxicology on preclinical compounds and analyze the resulting gene expression data. In these cases, researchers can gain access to the extensive and comprehensive DrugMatrix reference database to provide context for their analysis.

DrugMatrix Online is a chemogenomics reference database designed and built specifically for applications in pharmaceutical research and development. In DMO 1.0, 535 known drugs, withdrawn and failed molecules and reference biochemical and toxicological standards have been profiled by microarray gene expression. Each of the microarray experiments in the database is a biological triplicate and is associated with clinical chemistry, hematology, and organ histopathology data of the treated animal. Each of the 535 compounds profiled by microarray gene expression is also profiled in a suite of 127 pharmacological assays and is associated with detailed compound curation. The assembled chemogenomic profiles on each benchmark molecule are made available in an integrated informatics system that allows user-specific proprietary compounds to be compared, analyzed and prioritized using sophisticated bio- and chemoinformatics tools, including visualization of compound-specific effects on the expression of genes in 137 manually curated pathways.

A licensed user can access, search and manipulate this unparalled collection of reference information, applying a comprehensive set of analysis and visualization tools. The user can also securely upload Affymetrix gene expression data from studies on proprietary compounds, and apply these analysis tools to compare uploaded data to the reference collection in DMO. These comparisons include identification of reference compounds with similar gene expression profiles, identification of impacted pathways, pathway and Gene Ontology scoring, and scoring of uploaded compound data against Iconix proprietary Drug Signature Biomarkers in order to rapidly identify compound liabilities. A listing of some of the features available in DMO can be found in Table I.

Table I - DrugMatrix Online Version 1.0 Analysis Tools

An abbreviated set of specifications for DrugMatrix Online are linked here. The full specifications and capabilities are available by contacting the Iconix Customer Service.