Molecular Pharmacology Profiles The direct mechanism of action of a drug via its interaction with its various targets and off-target sites is critical to understanding the gene expression changes that it induces. In order to employ the expression data optimally to make accurate predictions of potential efficacy and toxicity of leads and drug candidates, all paradigm compounds are evaluated in a large standardized set of key molecular pharmacology assays to generate full in vitro activity and target interaction profiles. The fact that there is a homogeneous set of assays performed under uniform conditions makes it possible for the data to act as a reference set of information against which the assay profiles of novel compounds may be compared.

The current release of the database includes 130 key pharmacology bioassays performed by Ricerca Biosciences, a DrugMatrix partner and the world leader in this area. The initial assays were chosen to demonstrate off-target effects, including toxicology and drug metabolism. We have chosen assays for current research targets and target sites of leading drugs. In this first release, the profile consists of 90 receptor-type binding assays, 33 enzyme assays, and 7 ADME assays. The receptor assays cover a wide selection of receptor types in all the major therapeutic areas.