Toxicogenomics is a multidisciplinary field, combining genomics, molecular biology and traditional toxicology. Likewise, Informatics support for Toxicogenomics is multidimensional, requiring useful integration of data from genomics and toxicology, as well as a solid statistical foundation for working with large amounts of gene expression data.

Iconix has led the way in developing Informatics technologies that speed Toxicogenomic analyses.

Iconix Drug Signatures® are powerful classifier models that can diagnose or predict toxicological outcomes based on gene expression data from 3-5 day toxicology studies. Using Toxicogenomics and Drug Signatures can reduce the number of 30-day Tox studies run by your organization.

The Iconix Xtensible Informatics System (IXIS)™ is the most advanced integrated database and software system for working with Toxicogenomic data. IXIS fully supports data including genomics, gene expression from any microarray platform, pathways, pharmacology, curated literature facts, in-life study data, animal observations, histopathology, clinical chemistry, hematology, drug structures, and drug physical properties. Through our collaborations, Iconix has integrated powerful analytical (e.g. MDL ISIS chemical structure search) and data visualization (e.g. Spotfire) tools into the IXIS platform. IXIS also has a proprietary toolbox architecture that allows the development of new analytical tools that can be easily incorporated into the IXIS software.

ToxFX™ is another example of sophisticated Iconix Informatics technology. ToxFX is a fully-automated report generator, that takes microarray data as input and delivers a custom Toxicogenomics report in minutes.